Well, Lukey, you gotta find what works for you. As for me, I drew by hand for many years, still do for my initial roughs, but was never really satisfied with the final inking. I tried brush, crowquill, fountain pens, felt-tip pens, etc. The lines were always a bit "wobbly." Then I found Xtreme.
Xtreme to me is like a text editing program for a writer--every word, letter and paragraph is editable. Or, like a digital editor for music--every note, sound and effect can be easily edited, cloned, copied, deleted, etc. With Xtreme every line, color and shape can be independently manipulated and tweaked till you get it just right.
I do my original sketch by hand, then scan and import into Xtreme. Then I go over the lines with the stroke tool. I tried drawing in Photoshop and couldn't get the nice sharp crisp lines I was looking for. The lines looked fuzzy and, again, "wobbly."
For a description of how I work see http://www.zebtoonz.com/draw&color.htm.
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