To be honest, I've been using graphics tablets for many years and have never really made the effort to configure specific options and buttons. I guess it depends on how you work.

Once your hand/eye coordination gets settled in, it can be useful to open the Wacom Tablet properties utility. This then allows you to change the pen settings like click distance, tip feel and configure what the buttons do etc.

To me the biggest advantage of using a graphics tablet is just being able to draw and use pen and brush tools more naturally and accurately.