Quote Originally Posted by mwenz View Post
It may be possible to set that guide color and save it as a template and have it remain for future documents. I haven't tried it...
I can confirm this works. I created a named color, then set the guide color to that named color, and saved the template (and coincidentally set it as the default). Even with Delete Unused Colors turned on, it still retains the color I chose, so in opening new documents all my guides are light blue instead of the default red.

One caveat: This will cause the document to open with a Guides layer already in place, and you'll want to make sure the guide layer isn't selected when you save the template, or that will be the default selected layer when you open new documents. Rude awakening when you try to create shapes and they end up on the guide layer.

-- Ben