Depends on your printer! most will do a runs up to about 5000 without special die and just use the normal guillotine but it is all layout dependant. Ask your printer what size of paper he uses for small runs like this, in the UK most small print shop use SRA3 (320mm x 450mm) and then layout your docs. I would produce 2 docs, one front the other back but in this type of layout. You have got to be sure that both layouts mirror the final outcome and the imposition is done right or you can pay the printer to do your layout for you that is up to you. I always look at this is my job so if it goes wrong there is no one to blame bar yourself. I have developed links with my printer so if they see something is not right they will not go ahead until it is corrected. Please if you need any further help don't hesitate and come back but talk to your printer first.