Anybody use Page and Layout Designer to do roleplaying game material? I need to do PDFs for both electronic viewing and printing, as well as print on demand. I want to do lots of formatting, using sidebars, images, and graphics. I need to do double page spreads (except for the front and back cover) and format the left side pages differently than the right side pages.

I'm going to start layout for a Numenera adventure soon, and am wondering if this is a better tool than MS Publisher or PagePlus, and why?