Lately I'm finding it useful to make a layer and lock it with a hand drawn image from paper with 30% transparency above the actual image I'm vectoring. I do typically, though, just immediately group things a lot once they get locked down/finalized, but one of the advantages to layers I found is I don't have to waste a lot of effort drawing things behind stuff... Might use it a little more for this reason. I still like making entire image one layer in general, but for some things, it seems to have some advantages.
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