I think it comes down to the individual. Handrawn has suggested Manga Studio, many people like to use Xara for cartoons. Part of the decision comes down to whether you use a mouse or tablet and whther you like manipulating vector shapes or a more fluid interaction with pixels.
Rather than take someone else's advice, download some trials and see how you get on. You may well prefer Xara, or you may even adopt a hybrid approach using Xara with another program.
There is no "super" program that does everything well.
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