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I now have RegRun but never had a registry warning about Photoimpact

Are you running PI in Windows Vista? XP
Are you starting the application (right-click) 'Run as Administrator'? I start it from the desktop icon

Or

Do you have any registry protection...

Was this problem fixed in the latest version?

I always click on OK.....it just won't save the new settings in version 12

Every time I load PHOTOIMPACT 12 Autosave is set to 5 minutes.
I uncheck it and the next time I load the program it is there again.