It would be nifty if there were a way to adjust the size of the node handles, or the pixel range within which they are activated when clicking on or near them (if there is an option for this somewhere, please let me know because I seem to have missed it).
Often I am using the Shape Editor tool (absolutely the #1 most used tool for the kind of work I do), and when I go to click on a handle to move it, the system seems to think I've not clicked near enough to it, and it doesn't register. If it's an end node that happens to be selected, the result of this is that it draws another line segment, which I have to then Undo. If it's any other node, it ends up unselecting the desired node, and I have to click to reselect it. Half a second either way, I know, but when it happens dozens of times in a row, it can add up.